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These studies provide valuable insights into treatment approaches, but the lack of African-specific data on 5-ASA efficacy in IBD, such as precise patient numbers, remission rates, and long-term follow-up data, limits their applicability to clinical decision-making

Furthermore, a higher incidence of ALI with a direct pulmonary source may be associated with a higher frequency of ARDS and a higher mortality rate [18, 84], possibly due to poorer respiratory mechanics and lung elastance when compared to indirect insults [85]

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However, loosening of cell compartmentalization, which is part of the invasion process, is a necessary but not sufficient carcinogenetic event